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British Journal of Anaesthesia, 1972, Vol. 44, No. 11 1200-1204
© 1972 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

KETAMINE ANAESTHESIA IN PATIENTS WITH INTRACRANIAL PATHOLOGY

H. M. SHAPIRO, M.D., S. R. WYTE, M.D. and A. B. HARRIS, M.D.

Departments of Anes-thesiology and Neurosurgery and the Anesthesia Research Center, University of Washington School of Medicine Seattle, Washington 98195

Reprint requests to: Harvey M. Shapiro, M.D., University of Pennsylvania, Department of Anesthesia, 3400 Spruce Street, Philadelphia, Penn. 19104, U.S.A.

Intravenous ketamine anaesthesia induced abrupt increases in intracranial pressure levels ranging from 25 to 82 mm Hg on nine occasions in five patients with abnormal cerebrospinal fluid flow dynamics and/or other intracranial pathology. The mean gain in intracranial pressure in patients with cerebral abnormalities was 41.5 (SD 16.6) mm Hg. This is compared with a ketamine-induced mean pressure increase of 19.4 (SD 6.9) mm Hg found by other investigators in a group of neurologically normal patients. Intravenous injection of thiopentone may terminate intracranial pressure elevations caused by ketamine.


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