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British Journal of Anaesthesia, 1972, Vol. 44, No. 11 1169-1172
© 1972 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

THE EFFECT OF EPIDURAL ANALGESIA ON THE ADRENOCORTICAL RESPONSE TO SURGERY

D. LUSH, F.F.A.R.C.S*, J. N. THORPE, F.F.A.R.C.S, DOROTHY J. RICHARDSON, B.SC. and D. J. BOWEN, F.F.A.R.C.S

Departments of Anaesthetics and Biochemistry, Royal Hampshire County Hospital Winchester

In a study of four patients undergoing major gynaecological surgery under epidural analgesia together with general anaesthesia, it was found that epidural analgesia delayed but did not prevent a normal adrenocortical response to surgery. In the absence of surgery, epidural analgesia had no effect on plasma cortisol levels. It was concluded that complete alleviation of postoperative pain by neurogenic blockade does not prevent the normal adrenocortical response to surgery.

*Present address: Department of Anaesthetics, Southampton General Hospital, Tremona Road, Southampton


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