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British Journal of Anaesthesia, 1972, Vol. 44, No. 11 1128-1132
© 1972 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECTS OF ACUTE HYPOCAPNIA AND HYPERCAPNIA ON NEUROMUSCULAR TRANSMISSION AND ON MONOSYNAPTIC SPINAL REFLEX IN WAKEFUL MAN

HIDEHO HIGASHI, M.D., TATSUHIKO KANO, M.D., KOKI SHIMOJI, M.D., PH.D., TOHRU MORIORA, M.D., PH.D. and ANTHONY SANCES, JR., PH. D.

Department of Anesthesiology, Kumamoto University School of Medicine Honjo 1-1-1, Kumamoto, Japan
Department of Biomedical Engineering, Medical School of Wisconsin Milwaukee, Wisconsin, U.S.A.

The effects of both acute hypocapnia and hypercapnia on neuromuscular transmission (NMT) and monosynaptic spinal reflex (MSR) in conscious subjects were studied by observing the averaged evoked electromyogram. The M-wave amplitude increased to 165 ± 25% (mean ± standard error) during acute hypocapnia with an end expiratory carbon dioxide concentration of 2.5 ± 0.2 vol.% and decreased to 73 + 7% during acute hypercapnia with an expiratory concentration of 6.8 ±0.1 vol.%, in comparison with the control value. The H-wave amplitude increased to 226 ±82% during acute hypocapnia and decreased to 85 ± 9% during acute hypercapnia in comparison with the control value. These results indicate that both NMT and MSR in conscious man are facilitated by acute hypocapnia, and that NMT is inhibited by acute hypercapnia. However, the effect of acute hypercapnia on MSR could not be ascertained only by the observation of the H reflex in these conditions.


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